CHAPTER 5 HLA - DRB 1 * 03 : 01 and HLA - DRB 1 * 04 : 01 modify the presentation and outcome in autoimmune hepatitis type - 1
نویسندگان
چکیده
Nicole M.F. van Gerven*, Ynto S. de Boer*, Antonie Zwiers, Bart J. Verwer, Joost P.H. Drenth, Bart van Hoek, Karel J. van Erpecum, Ulrich Beuers, Henk R. van Buuren, Jannie W. den Ouden, Robert C. Verdonk, Ger H. Koek, Johannes T. Brouwer, Maureen M.J. Guichelaar, Jan M. Vrolijk, Minneke J. Coenraad, Georg Kraal, Chris J.J. Mulder, Carin M.J. van Nieuwkerk, Elisabeth Bloemena, Hein W. Verspaget, Vinod Kumar, Alexandra Zhernakova, Cisca Wijmenga, Lude Franke, Gerd Bouma
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Next Generation Sequencing Reveals the Association of DRB3*02:02 With Type 1 Diabetes
The primary associations of the HLA class II genes, HLA-DRB1 and HLA-DQB1, and the class I genes, HLA-A and HLA-B, with type 1 diabetes (T1D) are well established. However, the role of polymorphism at the HLA-DRB3, HLA-DRB4, and HLA-DRB5 loci remains unclear. In two separate studies, one of 500 subjects and 500 control subjects and one of 366 DRB1*03:01-positive samples from selected multiplex ...
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Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. In order to evaluate ...
متن کاملAssociation of the HLA locus and TNF with type I autoimmune hepatitis susceptibility in New Zealand Caucasians
PURPOSE The precise etiology of autoimmune hepatitis (AIH) remains unknown, although a number of genetic loci have been implicated in the susceptibility of type 1 AIH. The purpose of this study was to test for association of these loci with type 1 AIH in New Zealand Caucasians. METHODS 77 AIH patients and 485 healthy controls were genotyped for the SNPs rs2187668 (HLA-DRB*03:01), rs660895 (HL...
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Background: The outcome of acute hepatitis B infection may be influenced by host genetic factors like human leukocyte antigen (HLA). To investigate the association between the HLA-DRB, DQA1 and DQB1 alleles and chronic hepatitis B infection, 50 patients with chronic hepatitis B (based on 6 months positive of HBsAg and HBc antibody and HBeAg and antibody by serological test), were selected from ...
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The possible contribution of HLA-DRB3, -DRB4, and -DRB5 alleles to type 1 diabetes risk and to insulin autoantibody (IAA), GAD65 (GAD autoantibody [GADA]), IA-2 antigen (IA-2A), or ZnT8 against either of the three amino acid variants R, W, or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear. Next-generation sequencing (NGS) was used to determine all ...
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